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Francis Crick Quotes
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A theory should not attempt to explain all the facts, because some of the facts are wrong (Francis Crick Quotes)
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code (Francis Crick Quotes)
The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry (Francis Crick Quotes)
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place (Francis Crick Quotes)
Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene (Francis Crick Quotes)
The job of theorists, especially in biology, is to suggest new experiments. A good theory makes not only predictions, but surprising predictions that then turn out to be true (Francis Crick Quotes)
If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it (Francis Crick Quotes)
How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons (Francis Crick Quotes)
Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap (Francis Crick Quotes)
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets (Francis Crick Quotes)
A final proof of our ideas can only be obtained by detailed studies on the alterations produced in the amino acid sequence of a protein by mutations of the type discussed here (Francis Crick Quotes)
Almost all aspects of life are engineered at the molecular level, and without understanding molecules we can only have a very sketchy understanding of life itself (Francis Crick Quotes)
Biologists must constantly keep in mind that what they see was not designed, but rather evolved (Francis Crick Quotes)
To produce a really good biological theory one must try to see through the clutter produced by evolution to the basic mechanisms lying beneath them, realizing that they are likely to be overlaid by other, secondary mechanisms. What seems to physicists to be a hopelessly complicated process may have been what nature found simplest, because nature could only build on what was already there (Francis Crick Quotes)
Jim and I hit it off immediately, partly because our interests were astonishingly similar and partly, I suspect, because a certain youthful arrogance, a ruthlessness, an impatience with sloppy thinking can naturally to both of us (Francis Crick Quotes)
It is not easy to convey, unless one has experienced it, the dramatic feeling of sudden enlightenment that floods the mind when the right idea finally clicks into place. One immediately sees how many previously puzzling facts are neatly explained by the new hypothesis. One could kick oneself for not having the idea earlier, it now seems so obvious. Yet before, everything was in a fog (Francis Crick Quotes)
It is essential to understand our brains in some detail if we are to assess correctly our place in this vast and complicated universe we see all around us (Francis Crick Quotes)
There is no scientific study more vital to man than the study of his own brain. Our entire view of the universe depends on it (Francis Crick Quotes)
It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material (Francis Crick Quotes)
We are sometimes asked what the result would be if we put four ’s in one gene. To answer this my colleagues have recently put together not merely four but six ’s (Francis Crick Quotes)
Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid (Francis Crick Quotes)
Again the message to experimentalists is: Be sensible but don’t be impressed too much by negative arguments. If at all possible, try it and see what turns up. Theorists almost always dislike this sort of approach (Francis Crick Quotes)
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map (Francis Crick Quotes)
A comparison between the triplets tentatively deduced by these methods with the changes in amino acid sequence produced by mutation shows a fair measure of agreement (Francis Crick Quotes)
In the fullness of time, educated people will believe there is no soul independent of the body, and hence no life after death (Francis Crick Quotes)
What could be more foolish than to base one’s entire view of life on ideas that, however plausible at the time, now appear to be quite erroneous? And what would be more important than to find our true place in the universe by removing one by one these unfortunate vestiges of earlier beliefs? (Francis Crick Quotes)
An honest man, armed with all the knowledge available to us now, could only state that in some sense, the origin of life appears at the moment to be almost a miracle, so many are the conditions which would have had to have been satisfied to get it going (Francis Crick Quotes)
Haemoglobin is a very large molecule by ordinary standards, containing about ten thousand atoms, but the chances are that your haemoglobin and mine are identical, and significantly different from that of a pig or horse. You may be impressed by how much human beings differ from one another, but if you were to look into the fine details of the molecules of which they are constructed, you would be astonished by their similarity (Francis Crick Quotes)
In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He seemed to have very strong biological intuitions but unfortunately of negative sign (Francis Crick Quotes)
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority (Francis Crick Quotes)